Aquarter century ago, the World Bank revealed the first glimpse of the Global Burden of Disease Study (GBD). The study was met by many in the international health metrics sciences community with curiosity and skepticism. No one had ever attempted to quantify 107 diseases and injuries in every region of the world. Twenty-five years later, the GBD has evolved into a broad resource of what injures, disables, and kills people across countries, as well as by time, age, and sex. The 2017 study comprises seven papers and a complete edition of the international medical journal The Lancet. In addition, for the first time, the GBD seeks to quantify population and levels of fertility in every nation. The number of collaborators totaled 3,676 from 146 countries and territories; it includes 38 billion estimates of 359 diseases and injuries and 84 risk factors in 195 countries and territories.